news
horos news

Be up to date! Have a look at our most recent news, and if you want, you can also check the library for 

STAYS ABROAD, PROGRESS-REPORTS & CONGRESSES.

75 - Start of the next academic year
Date: 2021-10-19   Filed under: News

The new semester has started and we are very positive that we will soon come into a “post-pandemic” period. With the new academic year, also four new HOROS Associate students have started/will start very soon. They belong to the last PhD candidates that will be employed within the FWF funded doctoral college HOROS. However, the structure of HOROS will certainly remain at the Medical University of Innsbruck. The four students are: Adriana Koller under supervision of Prof. Kronenberg and Prof. Würzner, Patricia Caballero Fiz under supervision of Prof. Haas, Cristina Schöpf under supervision of Prof. Marx-Ladurner and Hussam Ab Del Halim under supervision of Prof. Weiss, Prof. Lass-Flörl and Prof. Wilflingseder. We wish them a good start into their exciting projects.

74 - HOROS Abroad - Verena is back from Copenhagen
Date: 2021-10-13   Filed under: News

COVID-19 travel restrictions made it unclear whether I can stay abroad at all. Fortunately, 2021 held its promises easing up those restrictions and I was able to travel to Denmark, the land of “Hygge”. I was hosted by the group of Dr. Peter Garred in the immunological research ward of the Rigshospitalet, the university clinic of the University of Copenhagen.

Dr. Peter Garred is a complementologist specialized in one of the complement activation pathways, the lectin pathway. Since my PhD topic is “Complement and complement-based therapy in invasive fungal infections”, we decided to collaborate with his team. The project I worked on in his laboratory was about a novel therapeutic approach for invasive aspergillosis. They identified a protein within the complement system, which binds to the cell surface of Aspergillus species, especially Aspergillus fumigatus, and coupled this protein to a mouse or human antibody. I checked these so-called Peptibodies for their sensitivity, specificity, stability and binding ability at different storage conditions, and the binding ability to different Aspergillus fumigatus strains to determine the Peptibody and the strain we will use for further in vivo experiments. Additionally, I tested the binding of MASP-3, a serine protease of the lectin pathway, to several yeasts and filamentous fungi, namely Cryptococcus species, Aspergillus fumigatus clinical and environmental isolates, and Apophysomyces variabilis.

The working group gave me a warm welcome and showed me around the city using the most popular transport system, the bike. Copenhagen is a beautiful city with a rich history; starting as a Vikings fishing village, going through rough times with epidemics and war, and finally evolving to the most populated city and capital of Denmark, which means there is a lot to explore. The people from the laboratory took me to museums, to some of the many parks, the famous marketplace Kongens Nytrov with the neighboring harbor Nyhavn, the winter residence of the Danish royal family Amalienborg, and many more. After the lockdown was lifted, we all got together for dinner and drinks.

I really enjoyed the stay in Copenhagen and want to thank the Ph.D. program HOROS, and especially Reinhard Würzner, for making it possible for me to gather new experiences in another laboratory and country. Additionally, I want to thank Peter Garred and his working group for their help and the warm goodbye, going out and giving me a scented candle and a nice little figurine with a spring, a so-called Hoptimist, which is now always at my desk in the office remembering me of my time there.

Nyhavn

Frederiks Kirke

Den lille Havfrue - the little mermaid

The genetically modified little mermaid

The global vizionary - sculpture made of scrap metal

Tristan Otto - Tyrannosaurus rex fossil 

Good Bye gift

 

73 - Zahra - the next HOROS Alumni
Date: 2021-10-05   Filed under: News

Congratulations to Zahra! She successfully defended her PhD thesis on 04th October 2021. Zahra studied the interaction of ZIKA with the complement system and authored two publications on that topic. More recently, she was also involved in invastigating the interplay of the SARS-CoV-2 virus and complement. We will definitely see more research-output from her in future. We are very happy to have another educated scientist and are curious, how Zahra will develop future - we wish you all the best :-)   

72 - HOROS ABROAD - Sara from Lund
Date: 2021-09-24   Filed under: News

The HOROS PhD Programme gifted me with the opportunity to spend 6 months abroad as a part of my PhD plan. My stay abroad started in May 2021 at Lund University, one of the most prestigious universities of Sweden and recognized worldwide.

My research project was held at Dr. Diana Karpman’s group, at the department of Pediatrics, Clinical Sciences Lund, at Lund University. Dr. Karpman and her group target on the pathogenesis of infectious and inflammatory renal diseases causing acute and chronic renal failure. Within this topic, one of their main projects is focused on enterohemorrhagic Escherichia coli (EHEC) infection and the development of hemolytic uremic syndrome (HUS). My PhD is addressed towards deciphering the role of EHEC’s main virulence factor, Shiga toxin, and other host factors in the development of E. coli-induced HUS (eHUS), therefore a stay at Dr. Karpman’s group was a perfect choice where to gain knowledge and useful techniques to expand my scientific experience in this field. The subproject that I worked on during my stay in Lund focused on investigating the importance of kallikrein-kinin system for the development of eHUS.

My tasks were very well organized since the very beginning to optimize the stay in the lab, however, achieve the objective was just possible thanks to the help of the people from Dr. Karpman’s lab. They taught me the techniques, ordered the necessary material and took their time to frequently discuss with me my results, giving me at the end suggestions how to improve each experiment.  Additionally, they also put effort in make me feel comfortable and welcomed in the team, and managed to convert me, a sedentary night owl, into an almost professional paddel player by training me weekly before work, making my stay in Lund remarkable also outside the lab.

Lund is a picturesque city located in the south-west of Sweden. The combination of its old history together with its young spirit obtained from the many students living there, makes Lund a very special place with a distinctive vibe. Despite being small, Lund has several beautiful parks, in which I spent most of my free time during spring and summer, the tulips at the Botanical garden in May were a spectacle on its own (check on the picture below). I will for sure come back in the future to visit this beautiful city again.

I am really grateful to HOROS PhD Program and my supervisor, Dr. Reinhard Würzner, for giving me this unique opportunity. Additionally, I would also like to thank Dr. Diana Karpman and her entire team for accepting this collaboration. It was a memorable experience.

 

Below find some pictures of my time in Lund:

Lund University - Library

Lund Cathederal

Lund City Centre

Botanical Garden - Tulips in June

Swedish Stew

Ale Stenar

Group Picture

 

horos news

Be up to date! Have a look at our most recent news, and if you want, you can also check the library for 

STAYS ABROAD, PROGRESS-REPORTS & CONGRESSES.



75 - Start of the next academic year
Date: 2021-10-19   Filed under: News

The new semester has started and we are very positive that we will soon come into a “post-pandemic” period. With the new academic year, also four new HOROS Associate students have started/will start very soon. They belong to the last PhD candidates that will be employed within the FWF funded doctoral college HOROS. However, the structure of HOROS will certainly remain at the Medical University of Innsbruck. The four students are: Adriana Koller under supervision of Prof. Kronenberg and Prof. Würzner, Patricia Caballero Fiz under supervision of Prof. Haas, Cristina Schöpf under supervision of Prof. Marx-Ladurner and Hussam Ab Del Halim under supervision of Prof. Weiss, Prof. Lass-Flörl and Prof. Wilflingseder. We wish them a good start into their exciting projects.



74 - HOROS Abroad - Verena is back from Copenhagen
Date: 2021-10-13   Filed under: News

COVID-19 travel restrictions made it unclear whether I can stay abroad at all. Fortunately, 2021 held its promises easing up those restrictions and I was able to travel to Denmark, the land of “Hygge”. I was hosted by the group of Dr. Peter Garred in the immunological research ward of the Rigshospitalet, the university clinic of the University of Copenhagen.

Dr. Peter Garred is a complementologist specialized in one of the complement activation pathways, the lectin pathway. Since my PhD topic is “Complement and complement-based therapy in invasive fungal infections”, we decided to collaborate with his team. The project I worked on in his laboratory was about a novel therapeutic approach for invasive aspergillosis. They identified a protein within the complement system, which binds to the cell surface of Aspergillus species, especially Aspergillus fumigatus, and coupled this protein to a mouse or human antibody. I checked these so-called Peptibodies for their sensitivity, specificity, stability and binding ability at different storage conditions, and the binding ability to different Aspergillus fumigatus strains to determine the Peptibody and the strain we will use for further in vivo experiments. Additionally, I tested the binding of MASP-3, a serine protease of the lectin pathway, to several yeasts and filamentous fungi, namely Cryptococcus species, Aspergillus fumigatus clinical and environmental isolates, and Apophysomyces variabilis.

The working group gave me a warm welcome and showed me around the city using the most popular transport system, the bike. Copenhagen is a beautiful city with a rich history; starting as a Vikings fishing village, going through rough times with epidemics and war, and finally evolving to the most populated city and capital of Denmark, which means there is a lot to explore. The people from the laboratory took me to museums, to some of the many parks, the famous marketplace Kongens Nytrov with the neighboring harbor Nyhavn, the winter residence of the Danish royal family Amalienborg, and many more. After the lockdown was lifted, we all got together for dinner and drinks.

I really enjoyed the stay in Copenhagen and want to thank the Ph.D. program HOROS, and especially Reinhard Würzner, for making it possible for me to gather new experiences in another laboratory and country. Additionally, I want to thank Peter Garred and his working group for their help and the warm goodbye, going out and giving me a scented candle and a nice little figurine with a spring, a so-called Hoptimist, which is now always at my desk in the office remembering me of my time there.

73 - Zahra - the next HOROS Alumni
Date: 2021-10-05   Filed under: News

Congratulations to Zahra! She successfully defended her PhD thesis on 04th October 2021. Zahra studied the interaction of ZIKA with the complement system and authored two publications on that topic. More recently, she was also involved in invastigating the interplay of the SARS-CoV-2 virus and complement. We will definitely see more research-output from her in future. We are very happy to have another educated scientist and are curious, how Zahra will develop future - we wish you all the best :-)   



72 - HOROS ABROAD - Sara from Lund
Date: 2021-09-24   Filed under: News

The HOROS PhD Programme gifted me with the opportunity to spend 6 months abroad as a part of my PhD plan. My stay abroad started in May 2021 at Lund University, one of the most prestigious universities of Sweden and recognized worldwide.

My research project was held at Dr. Diana Karpman’s group, at the department of Pediatrics, Clinical Sciences Lund, at Lund University. Dr. Karpman and her group target on the pathogenesis of infectious and inflammatory renal diseases causing acute and chronic renal failure. Within this topic, one of their main projects is focused on enterohemorrhagic Escherichia coli (EHEC) infection and the development of hemolytic uremic syndrome (HUS). My PhD is addressed towards deciphering the role of EHEC’s main virulence factor, Shiga toxin, and other host factors in the development of E. coli-induced HUS (eHUS), therefore a stay at Dr. Karpman’s group was a perfect choice where to gain knowledge and useful techniques to expand my scientific experience in this field. The subproject that I worked on during my stay in Lund focused on investigating the importance of kallikrein-kinin system for the development of eHUS.

My tasks were very well organized since the very beginning to optimize the stay in the lab, however, achieve the objective was just possible thanks to the help of the people from Dr. Karpman’s lab. They taught me the techniques, ordered the necessary material and took their time to frequently discuss with me my results, giving me at the end suggestions how to improve each experiment.  Additionally, they also put effort in make me feel comfortable and welcomed in the team, and managed to convert me, a sedentary night owl, into an almost professional paddel player by training me weekly before work, making my stay in Lund remarkable also outside the lab.

Lund is a picturesque city located in the south-west of Sweden. The combination of its old history together with its young spirit obtained from the many students living there, makes Lund a very special place with a distinctive vibe. Despite being small, Lund has several beautiful parks, in which I spent most of my free time during spring and summer, the tulips at the Botanical garden in May were a spectacle on its own (check on the picture below). I will for sure come back in the future to visit this beautiful city again.

I am really grateful to HOROS PhD Program and my supervisor, Dr. Reinhard Würzner, for giving me this unique opportunity. Additionally, I would also like to thank Dr. Diana Karpman and her entire team for accepting this collaboration. It was a memorable experience.

 

Below find some pictures of my time in Lund:

71 - Entrepreneurship @Sandoz
Date: 2021-09-24   Filed under: News

On rainy September 16, our cohort received a warm welcome at Sandoz, located in Kundl, Tyrol. Sandoz is a division of Novartis, and is specialized in the development and production of generics. These are small molecule drugs which resemble a reference drug of an originator company in all biochemical and biophysical properties. Once the 20-year term of an originator´s patent expires, generics can enter the market to create competition for a specific drug. This is essential to reduce the price of important medicines and increase their accessibility to people in need.

During the visit, students were organized in small groups and were familiarized with the general mission and vision of Sandoz as a company and the developmental process of a generic. All students had the exciting opportunity to be guided through an analytical lab of the pharmaceutical development department and the chance to ask questions regarding career prospects and what it is like to work in the pharmaceutical industry after obtaining a PhD. Some brain fuel in form of a lunch pack from Sandoz was much appreciated by everyone.

The day provided the students with many new insights into the industrial sector as an alternative to an academic career, and emphasized the importance to look at science from a different angle.

We want to give our special thanks to Stace, Selma, Peter, Olga and the rest of the team at Sandoz for this interesting and educative day!  



contact

PROGRAMME SPEAKER

Reinhard Würzner, M.D., Ph.D.
Schöpfstraße 41
A-6020 Innsbruck

horos@i-med.ac.at

Imprint

Partner
FWF INDEX W1253-B24