students
Franz Leonard Melzer
M.Sc. in Microbiology & Biotechnology
Institute for Biomedical Aging Research, Universit├Ąt Innsbruck, Austria
Regulatory CD8 T cells in old age

Regulatory T cells are a self-check subpopulation of T cells and are one of the most progressing T cell lines in task of research programs. Their main task is to prevent the immune system of excessive reactions. Besides their importance in the field of autoimmunity correlating with age and cancer causing disabilities, this cell type plays also an important role in the research of the so called subclinical uncontrolled processes referred to as ``inflammaging``.

Although CD8+ regulatory T cells have first been described to show immunosuppressive properties, it took quite a time to characterize a distinct phenotype whereas CD4+ regulatory T cells were intensively studied meanwhile.

Recently, CD8+ HLA-DR+ T cells were reported to have immunoregulatory porperties and as such, could play an important role in modulating the immune balance. We were able to prove this cell line as Regulatory T cells through my master thesis and checked their suppressive activity also in the old age where they show lower suppressive impact correlating with increased number of expression of this cell line. We also checked for the expression of the classical checkpoint inhibitory markers CTLA-4, PD-1, TIM-3 and LAG-3 where they showed decreased numbers in old age. At least we found out, that persons without CMV-infection show increased numbers of these mentionend molecules.

With my upcoming PhD I aim for a more detailed characterization of this cell line and what cell functions and what cell types correlating with age can get influenced by the activity of CD8+ HLA-DR+ Regulatory T cells. Therefore I hope to contribute to a better understanding of the immune system leading to a healthier aging.

Info
Nationality

German

why horos ?

"HOROS is an excellent PhD-program with interest in the newest research results and also offers great international networking opportunities. Through my Master thesis I was already able to gain experience as a group member of Prof. Grubeck-Loebenstein. I am really looking forward to learn more about my project but also to get new ideas by my great HOROS colleagues and widen my horizon and skillset."
Franz Leonard Melzer
Franz Leonard Melzer
M.Sc. in Microbiology & Biotechnology
Institute for Biomedical Aging Research, Universit├Ąt Innsbruck, Austria

Regulatory CD8 T cells in old age

Regulatory T cells are a self-check subpopulation of T cells and are one of the most progressing T cell lines in task of research programs. Their main task is to prevent the immune system of excessive reactions. Besides their importance in the field of autoimmunity correlating with age and cancer causing disabilities, this cell type plays also an important role in the research of the so called subclinical uncontrolled processes referred to as ``inflammaging``.

Although CD8+ regulatory T cells have first been described to show immunosuppressive properties, it took quite a time to characterize a distinct phenotype whereas CD4+ regulatory T cells were intensively studied meanwhile.

Recently, CD8+ HLA-DR+ T cells were reported to have immunoregulatory porperties and as such, could play an important role in modulating the immune balance. We were able to prove this cell line as Regulatory T cells through my master thesis and checked their suppressive activity also in the old age where they show lower suppressive impact correlating with increased number of expression of this cell line. We also checked for the expression of the classical checkpoint inhibitory markers CTLA-4, PD-1, TIM-3 and LAG-3 where they showed decreased numbers in old age. At least we found out, that persons without CMV-infection show increased numbers of these mentionend molecules.

With my upcoming PhD I aim for a more detailed characterization of this cell line and what cell functions and what cell types correlating with age can get influenced by the activity of CD8+ HLA-DR+ Regulatory T cells. Therefore I hope to contribute to a better understanding of the immune system leading to a healthier aging.


why horos ?
HOROS is an excellent PhD-program with interest in the newest research results and also offers great international networking opportunities. Through my Master thesis I was already able to gain experience as a group member of Prof. Grubeck-Loebenstein. I am really looking forward to learn more about my project but also to get new ideas by my great HOROS colleagues and widen my horizon and skillset.

info:
Principal Investigator:
Email:
Nationality:
German


contact

PROGRAMME SPEAKER

Reinhard Würzner, M.D., Ph.D.
Schöpfstraße 41
A-6020 Innsbruck

horos@i-med.ac.at

Imprint

Partner
FWF INDEX W1253-B24