The frequency of invasive fungal infections caused by Aspergillus species increased in recent years, primarily because of the use of intensive therapeutic regimens in patients with cancer, organ transplantation and particularly in the immunocompromised host due to their considerably high rates of morbidity and mortality. A. terreus is frequently found in the environment and the rate of nosocomial Aspergillosis caused by this fungus is less common than infections caused by other Aspergillus species, but the outcome of A. terreus infections is even more often fatal than other and therapy of infections caused by this species is complicated by its intrinsic resistance to Amphotericin B. So, the aim of this project is to evaluate the drug response of A.terreus according to new micro environmental and definitions that are based on techniques that would be able to clarify the notion of tolerance and persistence, which are too often confounded with the description of drug resistance in studies. The terminology and definitions behind these different mechanisms is often not properly used in studies and the terms “drug resistance” and “drug tolerance “are often used for reporting the same phenotypes, thus creating confusions. So studying a framework for classifying the drug response of fungal strains according to distinct definition for each phenotype is the goal of project.
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